The secret to cancer spread discovered

London Research Institute (LRI) scientists studying a virus have unveiled an important clue to understanding how cancer spreads. Their research is published in Nature* today (Wednesday).

They discovered that the dynamics of the protein N-WASP determines how fast the vaccina virus moves. The vaccinia virus was used as a vaccine to eradicate Smallpox.

The researchers hope that the mechanism used by this virus to move can be compared with cancer cells, and eventually help reveal how to slow down or stop the spread of cancer.

Dr Michael Way, lead author based at Cancer Research UK’s London Research Institute, said: “We discovered that a faster turnover of N-WASP results in the virus moving more quickly. We think this is reflected in a faster growth rate of actin filaments – which are chains of the actin protein under the virus that help it jump from one cell to another.

“We hope our understanding of how this protein regulates actin filament growth will help researchers to understand how tumour cells spread as the signalling pathway this virus uses is similar to the one used by tumour cells to invade other parts of the tissue.”

The movement of tumour cells from the primary tumour to other parts of the body is the main reason that cancer can be so difficult to treat. Preventing this is one of the major challenges for research.

Dr Lesley Walker, director of cancer information at Cancer Research UK, said: “The process of cancer cells breaking away from their tumour and spreading to other areas of the body is very complex. Understanding how this works can hopefully help us to develop more effective cancer treatments in the future.”

Technorati Tags: Actin Filaments, cancer cells, Cancer Information, Cancer Institute, Cancer Research Uk, Cancer Treatments, Chains, Clue, Dr Michael, Filament, Lesley, London Research, Lri, Protein, Research Dr, Smallpox, Tumour Cells, Turnover, Vaccinia Virus, Wasp

  
 April 13th, 2009 | Leave a Comment

What is the meaning of increased lymph nodes?

The ancient Greeks discovered that the human body except the red fluid to flow more transparent, and named it lymphomas, which in Greek means «pure water, humidity». Lymph flow in lymphatic vessels, cutting, and blood, our whole body. On the path of lymph vessels are lymph nodes. What are they for?

Filter it at in an instant

Every person has from 400 to 1000 lymph nodes in the body. They are in cavities and bends of the limbs, neck, under jaw, in the chest and abdominal cavities. They mature immune cells. Each node of days away «collects» lymph from a particular site and filter it from harmful impurities. They may be disease causing micro-organisms, faulty cells, alien proteins.

What happens to the impurities left in the lymph nodes? They attack the immune cells – macrophages, and literally consume the enemy. However, if the load on the site is great (for example, in the tissues from which lymph flows, there was inflammation), for him it does not pass without leaving a trace: site is becoming more and may even inflame. When the illness is passes, lymph node will decrease, but it will always be a little more dense than before.

How many hearts in the frog

The liquid portion of blood leaks out of capillaries in the intercellular spaces, forming lymph. She washes the fabric, and then going to the lymph vessels that return it to the veins. Some animals, such as fish, amphibians, reptiles and birds, under the skin in specific structures, which are called «lymphatic hearts» – they are the muscles that are contracting and push the liquid in one direction. In humans, these «hearts» no.

In young children who have no time to perebolet in your life can not be touching the lymph nodes under the skin, so they are soft and tiny. But who of us, adults, unfamiliar even with the cold? Therefore, our lymph nodes are also touched on the neck and under the jaw. Most people, however, the fold limbs, these biological «filters» remain the same as in infants – is not easy to find them, if that arm or leg has never been inflammation. It is more difficult with all the nodes located deep in the abdominal or thoracic cavity: do not touch and do not see it. There are times when even the experts are inflamed lymph nodes in the abdomen for appendicitis.

What will create lymph nodes

When the doctor feel lymph nodes, he drew attention to their quality: painful or not, whether they are large, knitted whether among themselves and with surrounding tissues. These characteristics may help to put an accurate diagnosis.

* Painless increase in lymph node is called lymphadenopathy and said that in the next nesting tissue disease.
* Painful increased lymph node (lymphadenitis), suggests that inflammation occurs within it. In this case, biological «filter» unable to cope with the harmful bacteria (a weakened immune system or infection especially strong) and exposed to attack by microbes. Sometimes it comes to suppuration, which is very dangerous: pus may form a phlegm: extensive spill between the layers of tissue (to remove it can only surgeon).
* If the lymph nodes are very dense and merge into a single sedentary range, the doctor may suspect the patient of malignant tumors.

Our cancer cells

Each of us formed up to 100 000 cancer cells per day – that is, those who because of a genetic “malfunction” changed the properties – from the envelope proteins in the ability to proliferate uncontrollably. They have another feature – they are easily separated from their places of origin and begin the journey through the body. The first thing they get into the lymphatic system and then dismantled in the lymph nodes. If a hereditary predisposition to cancer in humans is formed the same number of defective cells, like every other, but reduced their ability to filter the lymph nodes, as well as the ability of immune cells to find them and destroy the tissue.
When lowered immunity

When angina occurs local lymphadenopathy in the neck, and with sexually transmitted diseases – in the inguinal area. However, certain diseases cause generalized (ie, widespread) increase lymph  nodes. This happens, for example, in AIDS. On the one hand this is a good sign, meaning that the immune system is actively fighting the dangerous immunodeficiency virus, and on the other hand – a symptom of a terrible disease. AIDS as a result of waning immunity, and lymph nodes lose their ability to fight bacteria and cancer cells. Patients with HIV may die, but not from the virus, but from associated infections and tumors.

Six myths about AIDS
Only do not need to panic: most often, if you find yourself enlarged lymph node – the certificate of immunity works. In order to discover the cause of its activation, it is better to go to the doctor. A common cause of some random cat scratch, rhinitis, or a simple caries. Only a specialist can properly assess all the symptoms and to understand whether your condition is dangerous. Often do not require any special treatment of lymphatic system – but only to cure a tooth or a sore throat. During the life of any human lymph nodes increased many times, that does not count – and, as a rule, nothing horrible is not threatened.

Technorati Tags: AIDS, cancer cells, frog, Greeks, humidity, liquid portion of blood, Lymph, Lymph flow, pure water

  
 April 13th, 2009 | Leave a Comment

UK scientists have found cause of METASTASIS

The London Institute for Cancer Research found that the reason for the spread of metastases, which kills 90% of cancer patients is liziloksidaza enzyme (LOX). And now it can be stopped.

Cancer is so difficult to win because he is able to migrate throughout the body. If killed in tumor blood flow uplyla a single living cell, it can give rise to new, more aggressive tumors. And now confirmed what scientists long suspected. Way metastases thorite seemingly innocuous enzyme liziloksidaza. This protein, which in its composition of copper. He needs a body, as can “merge” the molecule of collagen and elastin – proteins that are normal heals wounds.

But it turned out that LOX plays and one more covert role. It suppresses the ability of tissue rejection reactions to “outsiders.” It also reports that the place for future tumor has already been prepared, you can migrate.

Principal Investigator Janine Erler said:

- The opening is a critical missing element “pazzla” – a puzzle that scientists have long tried to collect. If we can reduce the activity of LOX, it can prevent the formation and metastasis.

In connection with the discovery, published in the fresh issue of the journal Cancer Cell Journal, will recall the great German Rudolf Virhova – the man who first realized that we are composed of cells. It is still more than a hundred years ago, said: “Cancer – this is an open wound.” Bearing in mind that the body perceives as a malignant cell and therefore fitted the wound to her enormous resources in trying to live as a normal wound. These resources and allow the cancer cells divide late as deteriorated. But in the end it is so completely depletes immunity, and people die.

  
 April 13th, 2009 | Leave a Comment

Delay in diagnosis was a mistake

Sparta woman learns it’s never too late
By Greg England, Staff Writer
greg@myspartanews.com, Published: Monday, April 13, 2009 8:20 AM CDT

White County resident Helen Regas noticed a lump in her breast in 2005 but waited two years to see a doctor about it.

She is like most people. She dreaded even the possibility of cancer. Her fear of the unknown caused her to put it off, hoping it was nothing or that it would go away.

“I had a little lump that I was feeling on the left side, which I left for a long time,” said Regas. “It was my fault. George (her husband) told me and my mother told me I should go. We were talking, and my husband encouraged me to go, don’t be scared. We have to face it – whatever it is.”

The lump did not go away. She wondered how could it happen to her. She never smoked, and there was no family history of cancer.

Helen’s life has always been filled with work and family. Her fear of the truth, which might disrupt or possibly end her life, caused her to delay going to the doctor.

“I talked to my doctor after it happened, and he said, ‘Helen, it’s the reaction of most of the people,’” she said. ‘You’re just scared and put it in the back of your mind and say it’s nothing, you know. Just forget about it, and keep on going.’ I think that’s what I did, and it was my mistake.”

In 2007, Helen went to the doctors at the Breast Cancer Center at Vanderbilt after much prodding from her family, including her daughter and two sons.

Tests results confirmed her fears. She had cancer in both breasts.

“We were petrified,” said Helen. “We called our children to inform them about the bad news. We were all devastated.”

A plan was developed for Helen to start receiving treatments, beginning with the removal of five lymph nodes – three on one side and two on the other.

Cancer attacks different parts of the body by moving through the different systems of the body, like the lymph nodes.

A CAT Scan had revealed trouble with her thyroid and adrenal glands.

“In every case, they treat it differently,” stated Helen. “They thought, in my case, the best thing to do was to have a surgery and take my lymph nodes.”

Her first good news was her lymph nodes were clear.

The possibility of the cancer metastasizing (or spreading) to other areas of her body was greater because it had time to grow and move. Chemotherapy was the next step in her treatment.

“I had to go through more tests and stuff because I delayed it so long,” said Helen. “The chemo was the strongest they could give me. The radiation and all the treatments were stronger.”

Chemotherapy is used to reduce the size of cancer masses and keep it contained so surgery can be used to remove it with a greater chance of getting all of it.

“Some of my chemo treatments did not have side effects, but three sessions were severe,” stated Helen. “I had all the side effects you could imagine: nausea, terrible sensitivity of smell, allergic reaction to the medicine, muscle pain, restless leg syndrome, and more. The most severe side effect that affected me psychologically was the hair loss.”

Helen has always had beautiful, thick hair.

“Standing by the mirror of my bathroom, pulling out big chunks of my hair and throwing it in a little bucket was torture,” said Helen. “I cried as the shower water washed away what was left of my hair.”

After three and a half months of chemo, Helen received surgery to remove the cancerous mass.

“My second surgery came a month after my chemo was completed,” stated Helen. “It was the beginning of November.”

Testing had revealed the cancer in her left breast was the type that could easily metastasize (or spread), while the right breast was not.

Helen was given a choice – mastectomy on both breasts, mastectomy on the left and lumpectomy on the right, or lumpectomy on both. When a mastectomy is performed, the entire breast tissue is removed.

With the help of her family who remained by her side every step of the way, Helen chose to treat both breasts by lumpectomy, which involves removing just the cancerous tissue.

“The most important thing was that it had not spread to any other organs and it was a slow-growing type of cancer,” said Helen.

But news from her doctor after the surgery was the procedure had not completely rid her of the cancer. Another surgery was performed, which was a success.

“I started to have hope again, and my life gradually started to become normal,” stated Helen.

Next, radiation therapy was administered to kill any remaining cancer cells. She received her last radiation treatment in February 2008.

She began regular check-ups every three months. The doctor visits have now been reduced to every six months. That will continue for five years.

“My fight against cancer is not over, but I am a survivor,” stated Helen.

She has several doctors who closely check for any signs of the cancer coming back.

Helen says her family is what has kept her going.

“I have such a great family,” said Helen. “I do it for my husband and my kids, basically. If they were not here, I don’t know if I would do it. But I’m fine. I think that God gives you one thing to try you, then he gives you courage to go through it. That’s what I believe.”

She has recurring muscle and joint pain but she shrugs that off because she knows how blessed she has been.

“Sometimes you forget to enjoy life – the simple things,” stated Helen. “And I believe that’s what it taught me, to enjoy the little things like a beautiful day.”

Helen’s experience has taught her some important lessons. She says being pro-active is the right thing to do.

“People should go and check themselves and don’t wait like me,” said Helen. “I think a lot of women wait, like me, until it’s too late sometimes.”

She explains the fight against cancer depends on early detection and the decision to be checked affects friends and family.

“You have to fight,” stated Helen. “It’s not only you. There are other people around you that care for you and you can’t do that to them. Sometimes you get discouraged and you say, uh, I’m gonna give up. But you can’t give up. You have to fight.”

Helen suggests women should have a yearly mammogram. She offered a phone number for women ages 40 to 64 who have no insurance or a deductible of $1,000 or higher to get help, advice, and even free mammograms. That number is (931) 646-2222.

“I was bad, and that’s why I encourage people to go, because I did the wrong thing myself, and I don’t want other people to go through what I did,” said Helen. “I encourage them to go and go early. One in seven women will have some kind of problem, even if it’s a cyst or it’s not really cancer. But they need to find out and do it early.”


Technorati Tags: cancer side-effects, Delay in diagnosis, Saving money, Stress, timing

  
 April 13th, 2009 | Leave a Comment

WHY DO SO MANY PEOPLE STILL DIE OF CANCER?

These are quotes from Dr. Simonchiny presentation in Rome.

The question that many people ask themselves is why, after so many years of study and research, has cancer not yet been defeated?

The problem is indeed scientific, but in my opinion it is even more a problem of a cultural and social nature as it represents the very structure of knowledge at the world level – a structure that prevents that freedom of thought and creativity that is capable of finding the right solutions.

The politicized structure of universities and professional orders which are set up almost as castes, with financing issued only to established institutions that are often almost mummified, and the monopoly of information held by existing political and cultural powers – all these are elements that prevent the most fertile and creative minds of society from having the slightest chance of exploring new paths. This fossilized social attitude is forcing entire populations to exist in a chronic state of fear and suffering when it comes to a disease – cancer – which could be successfully defeated.

Some time ago a patient with cancer sought my help. As I was explaining my mycotic theory on cancer to her, she commented “This perspective at least gives me the dignity to be ill. An infection makes sense.”

TULLIO SIMONCINI from J3njy on Vimeo.

His vision is impressive:

In the future – I hope soon – I am convinced that it will be possible to treat and cure any tumor within 15-30 days with either a pill or an injection in the morning and in the evening when there is targeted pharmacological research. But, again, we now have to work with what we have.
Since the administration of bicarbonate is valid and simple to perform, we must act as much as possible on empowering the defensive abilities of the organism and attempting to exploit all the facilitating elements.
We can contemplate the future of benefits and knowledge that the application of this simple technique will bring. A great vista will open for medicine where all therapeutic methods and conceptions of health currently held will have substance and a logical rationale.

Technorati Tags: Attitude, Bicarbonate, Cancer Help, Cancer personal stories, cancer side-effects, Castes, Chronic State, Creative Minds, Creativity, Defensive Abilities, Dignity, Elements, Freedom Of Thought, Institutions, luminific, Monopoly, Organism, Perspective, Pharmacological Research, Populations, Professional Orders, Right Solutions, Rome, SIMONCINI CANCER THERAPY, Social Nature, State Of Fear, Suffering, Tullio Simoncini, Tumor, Vimeo

  
 April 12th, 2009 | Leave a Comment

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